Which events are considered PHEIC events requiring notification on the Annex 2?

The correct answer is based on the criteria set forth in the International Health Regulations (IHR) for declaring a Public Health Emergency of International Concern (PHEIC). PHEIC events require specific situations that highlight a serious threat to public health across borders.

The criteria for a PHEIC encompass public health events that are determined by risk factors such as the potential to spread internationally, the severity of the impact on health, and the need for coordinated international response. Specifically, if an event meets any two out of four situational public health criteria outlined in the IHR, it qualifies as a PHEIC that necessitates notification on Annex 2.

This framework ensures that only significant health threats, which have the potential to disrupt global health security, are reported. Therefore, the correct answer aligns with the established regulations governing public health emergencies, making it crucial for maintaining global health vigilance and response mechanisms.

Events in developed countries alone may not necessarily trigger a PHEIC if they do not pose a risk of international spread or have other serious implications according to the outlined criteria. Similarly, while vaccine-preventable diseases are critical, not all outbreaks of such diseases automatically qualify as PHEIC events without a context that involves broader implications. Outbreaks